Onchocerciasis

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The disease begins when a human host is bitten by an infected female black fly.   Some people are bitten up to 10,000 times by the tiny black fly.
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Humans acquire the disease while fulfilling their regular daily activities.   Activities near fast-moving rivers are especially risky.
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Skin manifestations of the disease include the presence of nodules containing adult female and male worms.   Adult worms in the nodules are clumped together.
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Microscopic larvae produced by the thousands by adult worms are the primary cause of the disease.   A rash is the common first sign of the disease.
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Loss of pigment in the legs develops soon after.   Loss of elasticity of the skin causes this condition.
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Damage to the eye includes opacity of the lens and the destruction of the optic nerve.   The disease eventually results in complete blindness.
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Three approaches to the control of riverblindness.   The disease is widespread in the Congo.
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Mectizan is the current drug of choice in the fight against riverblindness.   Merck will provide Mectizan as long as necessary to control and eliminate the disease worldwide.